placental chrorionic pseudocysts

Synopsis

 grossly apparent and microscopically intermediate trophoblast-lined subchorionic, septal and cell island cysts (17378641)

 grossly inapparent microscopic chorionic pseudocysts (lakes) arising in the chorion laeve of placental membranes (MCCPM) (17378641)

 Mccpm are observed in 4.3% of all placentas and in 14.9% of placentas from preeclamptic mothers from 24-41 weeks pregnancy. (17378641)

 Mccpm are statistically significantly more common in preeclampsia and maternal diabetes mellitus. (17378641)

 In placentas with mccpm, decidual arteriolopathy, homogenous placental maturation, global hypoxic pattern of placental injury, chorangiosis, placental infarction, laminar necrosis of membranes, stem obliterative endarteritis, erythroblasts of fetal blood, and decidual hemosiderosis were statistically significantly more common, while acute chorioamnionitis, vilous fibrosis, and villous edema less common. (17378641)

 No positive or negative correlations with meconium staining, retroplacental hematoma, perivillous fibrin deposition, intervillous thrombi, chronic villitis, chorangiomas, placenta accreta, amnion nodosum, and marginate/vallate placenta. (17378641)

 Highly statistically significant associations of mccpm with preeclampsia and a cluster of placental lesions known to be linked to placental hypoxia indicate that the mccpm form in response to hypoxia, particularly in preeclampsia. Mccpm should therefore be regarded and reported as a hypoxia-associated placental lesion. (17378641)

References

 Stanek J, Weng E. Microscopic chrorionic pseudocysts in placental membranes: a histologic lesion of in-utero hypoxia. Pediatr Dev Pathol. 2007 Mar 22;:1 PMID: 17378641